Add to ORKGSjögren\u27s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren\u27s cases of European ancestry: CD247, NAB1, PTTG1-MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP6, TYK2, SYNGR1. Polygenic risk scores yield predictability (AUROC = 0.71) and relative risk of 12.08. Interrogation of bioinformatics databases refine the associations, define local regulatory networks of GWS SNPs from the 95% credible set, and expand the implicated gene list to \u3e40. Many GWS SNPs are eQTLs for genes within topologically associated domains in immune cells and/or eQTLs in the main target tissue, sali...
Sjögren's syndrome (SS) is a late-onset chronic autoimmune disease (AID) affecting the exocrine glan...
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide associatio...
Autoimmune diseases occur when an individual’s own immune system attacks and destroys his or her hea...
Sjögren\u27s disease is a complex autoimmune disease with twelve established susceptibility loci. Th...
Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
Sjogren's disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
International audienceSjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European...
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typic...
Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of...
Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studi...
ObjectiveThe Sjögren's International Collaborative Clinical Alliance (SICCA) is an international dat...
Sjogren's syndrome (SS), a chronic autoimmune disease, typically causes or involves inflammation in ...
An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune sy...
Sjögren's syndrome (SS) is a late-onset chronic autoimmune disease (AID) affecting the exocrine glan...
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide associatio...
Autoimmune diseases occur when an individual’s own immune system attacks and destroys his or her hea...
Sjögren\u27s disease is a complex autoimmune disease with twelve established susceptibility loci. Th...
Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
Sjogren's disease is a complex autoimmune disease with twelve established susceptibility loci. This ...
International audienceSjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European...
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typic...
Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of...
Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studi...
ObjectiveThe Sjögren's International Collaborative Clinical Alliance (SICCA) is an international dat...
Sjogren's syndrome (SS), a chronic autoimmune disease, typically causes or involves inflammation in ...
An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune sy...
Sjögren's syndrome (SS) is a late-onset chronic autoimmune disease (AID) affecting the exocrine glan...
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide associatio...
Autoimmune diseases occur when an individual’s own immune system attacks and destroys his or her hea...