Formulation and Evaluation of Sustained Release Tablets of Gemifloxacin using Natural Polymers

The present work to aim the design, fabrication and evaluation of Gemifloxacin sustained release tablets by wet granulation technique. In this technique Guar Gum and Xanthan Gum were used as polymers for drug released upto extended time period.The Formulations F6 found to satisfy the desired criteria for GFX released from the formulation. The drugs released from the formulations and released mechanism followed for “first order kinetics& Non-Fickian diffusion mechanism” respectively.Finally to achieve a Gemifloxacin sustained released tablets and drugs released up to 12hrs. There are several reasons for attractiveness of these dosage forms: provides increased bioavailability of drug product, reduction in the frequency of administration to prolong duration of effective blood levels, reduces the fluctuation of peak through concentration and side effects and possibly improves the specific distribution of the drug. If one were to develop an ideal drug delivery system, two prerequisites would be required: Firstly single dose for the duration of treatment whether for days or weeks as with infection, diabetes or hypertension. Second, It should deliver the active entity directly to the site of action minimizing the side effects