Design, Development and Evaluation of Herbal Extract Loaded Nanogel of Abutilon Indicum Linn for Hemorrhoids

The Aim of the present study is to formulate and evaluate the nanogel of ABUTILON INDICUM LINN. The objective of the work is satisfied with the following methodology: The authenticated plant leaf was powdered and transferred to the soxhlet apparatus for crude drug extraction by using ethanol (500ml). The process is maintained in 60 ˚C for 8 hours. The extract was collected in round bottom flask and concentrated by heating. Finally it was stored in suitable temperature. 2ml of extract was used in different 5 trials (ANGF1 TO ANGF5) Then prepared nanogel was subjected to evaluation test. In ABUTILON INDICUM LINN many formulation were reported for different activities like Anti inflammatory activity, Lipid lowering activity, Analgesic activity, Antioxidant and antibacterial activity, Hepatoprotective activity, Hypoglycemic activity, Antidiarrhoeal activity but now this novel formulation of nanogel in ABUTILON INDICUM LINN is mainly focusing on hemorrhoids. One out of four of human population may suffer with hemmorrhoidal symptoms atleast once in life time so this formulation may be effective and beneficial for the society. From the results of the present experimental investigation, it may be concluded that the formulation of ABUTILON INDICUM LINN nanogel showing small vesicle size, with desire release of ABUTILON INDICUM LINN. Hence, ANGF5 is the optimized formulation. The optimized formulation was found to follow zero order release pattern which was revealed by the linearity shown from the plot of Time vs Concentration. So we can conclude that ABUTILON INDICUM LINN nanogel facilitate higher cellular penetration and possess high bioavailability and sustained release