Formulation and Evaluation of Sustained Release Solid Oral Dosage Form of a Calcium Channel Blocker

In the present work, an investigation was made to use sodium alginate, methocel K100 LVCR polymer in the design and development of sustained release oral drug delivery systems. Calcium channel blocker was chosen as the model drug with the view of formulating sustained release matrix tablets to improve its bioavailability. 1. Drug-excipient compatibility studies were proved by using FTIR. 2. The sustained release matrix tablets of calcium channel blocker were formulated by wet granulation method. 3. The formulated tablets was evaluated for all the official test (as per USP39) 4. The polymer sodium alginate and methocel K100 LVCR showed better dissolution control proficient compared to the other polymers like Methocel K100 LV premium, HPMC K100M, HPMC K4M. 5. The release kinetics of all formulations showed that the drug release followed Non-Fickian transport (Diffusion and erosion). 6. The release kinetics of optimized formula showed Non-fickian transport followed by zero order indicating drug release behavior through diffusion and erosion mechanism