Formulation and Charecterization of Artemisinin Nanoparticles

The active pharmaceutical ingredient Artemisinin was evaluated for its Organoleptic properties and solubility. The results obtained were satisfactory. Artemisinin nanoparticles were prepared by emulsion-droplet coalescence method and the polymer concentrations were optimized by various trials In the present study Chitosan nanoparticles containing Artemisinin was prepared. The effect of increase in Chitosan concentration on various parameters like particle size, zeta potential,Entrapment Efficiency and invitro release profile were studied. The results showed that the in vitro drug release for ANP1, ANP2, ANP3, ANP4 and ANP5 were found to be 98.51%, 98.54%, 98.54%, 98.57% and 85.77% respectively at the end of 24hrs. Based on the drug content,entrapment efficiency,particle size,zeta potential and in vitro drug release profile of Artemisinin nanoparticles formulations (ANP1-ANP5) formulation ANP4was selected as the best formulation in which the particle size was 637.2 nm. The in vitro % drug release of ANP4 formulation was 98.57% and it was found to be suitable formulation to treat Malaria. Hence it can be concluded that the newly formulated controlled release nanoparticulate drug delivery systems of Artemisinin may be ideal and effective in the treatment of Malaria by allowing the drug to release continuously for 24 hr