The aim of this paper is the investigation of gravity currents moving on beds with different slopes by both laboratory experiments and numerical simulations. Laboratory experiments are performed by full-depth lock exchange release and an image analysis technique is applied to measure the space-time evolution of the gravity current's profile. A two-layers, 2D, shallow-water model is used to simulate gravity currents. The model takes into account the space-time evolution of free-surface and the mixing due to the gravity current. Entrainment at the interface between the gravity current and the ambient fluid is modeled by a modified Ellison & Turner’s formula (1959). Several tests are run to calibrate an entrainment parameter in order to reprod...