Neurological disorders affect billions of people across the world, making the discovery of effective treatments an important challenge. The evaluation of drug efficacy is further complicated because of the lack of in vitro models able to reproduce the complexity of the human brain structure and functions. Some limitations of 2D preclinical models of the human brain have been overcome by the use of 3D cultures such as cell spheroids, organoids and organs-on-chip. However, one of the most promising approaches for mimicking not only cell structure, but also brain architecture, is currently represented by tissue-engineered brain models. Both conventional (particularly electrospinning and salt leaching) and unconventional (particularly bioprinti...
The new cellular models based on neural cells differentiated from induced pluripotent stem cells hav...
To highlight the particular needs with respect to modeling the unique and complex organization of th...
Human pluripotent stem cells (hPSCs) have great potential in regenerative medicine, disease modeling...
Neurological disorders affect billions of people across the world, making the discovery of effective...
Nervous system disorders including acute traumatic injuries, neurodegenerative diseases, and neurode...
Nervous system disorders including acute traumatic injuries, neurodegenerative diseases, and neurode...
In the last decade, the advances made into the reprogramming of somatic cells into induced pluripote...
As the human population is getting older, neurodegenerative diseases are becoming an increasing thre...
Inherent limitations of the traditional approaches to study brain function and disease, such as rode...
Inherent limitations of the traditional approaches to study brain function and disease, such as rode...
Engineered three-dimensional (3D) in vitro and ex vivo neural tissues, also known as “mini brains an...
Animal models have been greatly contributing to our understanding of physiology, mechanisms of disea...
There is a fundamental need for clinically relevant, reproducible, and standardized in vitro human n...
BACKGROUND: Three-dimensional (3D) in vitro models have been developed into more in vivo resembling ...
The human brain is arguably one of the most complex structures known to humankind. To understand the...
The new cellular models based on neural cells differentiated from induced pluripotent stem cells hav...
To highlight the particular needs with respect to modeling the unique and complex organization of th...
Human pluripotent stem cells (hPSCs) have great potential in regenerative medicine, disease modeling...
Neurological disorders affect billions of people across the world, making the discovery of effective...
Nervous system disorders including acute traumatic injuries, neurodegenerative diseases, and neurode...
Nervous system disorders including acute traumatic injuries, neurodegenerative diseases, and neurode...
In the last decade, the advances made into the reprogramming of somatic cells into induced pluripote...
As the human population is getting older, neurodegenerative diseases are becoming an increasing thre...
Inherent limitations of the traditional approaches to study brain function and disease, such as rode...
Inherent limitations of the traditional approaches to study brain function and disease, such as rode...
Engineered three-dimensional (3D) in vitro and ex vivo neural tissues, also known as “mini brains an...
Animal models have been greatly contributing to our understanding of physiology, mechanisms of disea...
There is a fundamental need for clinically relevant, reproducible, and standardized in vitro human n...
BACKGROUND: Three-dimensional (3D) in vitro models have been developed into more in vivo resembling ...
The human brain is arguably one of the most complex structures known to humankind. To understand the...
The new cellular models based on neural cells differentiated from induced pluripotent stem cells hav...
To highlight the particular needs with respect to modeling the unique and complex organization of th...
Human pluripotent stem cells (hPSCs) have great potential in regenerative medicine, disease modeling...