Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European liver transplant registry
- Adam, R
- Karam, V
- Delvart, V
- Trunecka, P
- Samuel, D
- Bechstein, Wo
- Nemec, P
- Tisone, G
- Klempnauer, J
- Rossi, M
- Rummo, Oo
- Dokmak, S
- Krawczyk, M
- Pratschke, J
- Kollmar, O
- Boudjema, K
- Colledan, M
- Ericzon, Bg
- Mantion, G
- Baccarani, U
- Neuhaus, P
- Paul, A
- Bachellier, P
- Zamboni, F
- Hanvesakul, R
- Muiesan, P
DOIAbstract
This study was a retrospective analysis of the European Liver Transplant Registry (ELTR) performed to compare long-term outcomes with prolonged-release tacrolimus versus tacrolimus BD in liver transplantation (January 2008-December 2012). Clinical efficacy measures included univariate and multivariate analyses of risk factors influencing graft and patient survival at 3 years posttransplant. Efficacy measures were repeated using propensity score-matching for baseline demographics. Patients with <1 month of follow-up were excluded from the analyses. In total, 4367 patients (prolonged-release tacrolimus: n = 528; BD: n = 3839) from 21 European centers were included. Tacrolimus BD treatment was significantly associated with inferior graft (risk...
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