Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma
- Hohaus, S
- Di Ruscio, A
- Di Febo, A
- Massini, G
- D'Alo', F
- Guidi, F
- Mansueto, G
- Voso, MT
- Leone, G
DOIAbstract
Glutathione S-transferase P1 (GSTP1) is a member of the GST enzyme superfamily that is important for the detoxification of several cytotoxic drugs and their by-products. A single nucleotide polymorphism results in the substitution of isoleucine (Ile) to valine (Val) at codon 105, causing a metabolically less active variant of the enzyme. We assessed the impact of the GSTP1 codon 105 genotype on treatment outcome in patients with Hodgkin's lymphoma
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