The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scrutinized as biomarkers for human disease. An endocrine/neuromodulatory role for VGF peptides has been suggested but never demonstrated. Furthermore, no study has demonstrated so far the existence of a receptor-mediated mechanism for any VGF peptide. In the present study, we provide a comprehensive in vitro, ex vivo and in vivo identification of a novel pro-lipolytic pathway mediated by the TLQP-21 peptide. We show for the first time that VGF-immunoreactivity is present within sympathetic fibres in the WAT (white adipose tissue) but not in the adipocytes. Furthermore, we identified a saturable receptor-binding activity for the TLQP-21 peptide. ...
VGF is a propeptide of 617 amino acids expressed throughout the central and the peripheral nervous s...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
vgf is an inducible gene implicated in the regulation of energy balance. Its derived gene product, V...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 centrally exerts catab...
TLQP-21 and TLQP-62, two peptides encoded by the VGF (non-acronymic) gene product, are expressed in ...
Objectives: Obesity is characterized by excessive fat mass and is associated with serious diseases s...
VGF encodes a precursor protein processed in various neuropeptides, one of these involved in metabol...
AbstractRecently, we demonstrated that TLQP-21 triggers lipolysis and induces resistance to obesity ...
We investigated a possible role of the central glucagon-like peptide (GLP-1) receptor system as an e...
<div><p>To address the possible involvement of VGF peptides in obesity and diabetes, we studied type...
To address the possible involvement of VGF peptides in obesity and diabetes, we studied type 2 diabe...
VGF is a propeptide of 617 amino acids expressed throughout the central and the peripheral nervous s...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
vgf is an inducible gene implicated in the regulation of energy balance. Its derived gene product, V...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor ...
The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 centrally exerts catab...
TLQP-21 and TLQP-62, two peptides encoded by the VGF (non-acronymic) gene product, are expressed in ...
Objectives: Obesity is characterized by excessive fat mass and is associated with serious diseases s...
VGF encodes a precursor protein processed in various neuropeptides, one of these involved in metabol...
AbstractRecently, we demonstrated that TLQP-21 triggers lipolysis and induces resistance to obesity ...
We investigated a possible role of the central glucagon-like peptide (GLP-1) receptor system as an e...
<div><p>To address the possible involvement of VGF peptides in obesity and diabetes, we studied type...
To address the possible involvement of VGF peptides in obesity and diabetes, we studied type 2 diabe...
VGF is a propeptide of 617 amino acids expressed throughout the central and the peripheral nervous s...
Structural and functional diversity of peptides and GPCR result from long evolutionary processes. Ev...
vgf is an inducible gene implicated in the regulation of energy balance. Its derived gene product, V...