Electromotive versus passive diffusion of mitomycin C into human bladder wall: concentration-depth profiles studies

  • Di Stasi, S
  • Giannantoni, A
  • Massoud, R
  • Dolci, S
  • Navarra, P
  • Vespasiani, G
  • Stephen, R
Publication date
October 1999

Abstract

The objectives of these investigations were: (a) to make a preliminary study to assess concentration-depth profiles of mitomycin C (MMC) in the bladder wall at specified time intervals after passive diffusion (PD); and (b) to conduct a major study to compare concentration-depth profiles after PD and electromotive drug administration (EMDA) of MMC. Full thickness sections of viable human bladder wall were placed in two-chamber cells with urothelium exposed to donor compartments containing 40 mg of MMC in 100 ml of 0.96% NaCl solutions and with serosa-facing receptor compartments containing 0.9% NaCl solutions. In the preliminary study during each of nine experimental sessions, five sections of bladder wall were individually exposed to MMC fo...

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