The objectives of these investigations were: (a) to make a preliminary study to assess concentration-depth profiles of mitomycin C (MMC) in the bladder wall at specified time intervals after passive diffusion (PD); and (b) to conduct a major study to compare concentration-depth profiles after PD and electromotive drug administration (EMDA) of MMC. Full thickness sections of viable human bladder wall were placed in two-chamber cells with urothelium exposed to donor compartments containing 40 mg of MMC in 100 ml of 0.96% NaCl solutions and with serosa-facing receptor compartments containing 0.9% NaCl solutions. In the preliminary study during each of nine experimental sessions, five sections of bladder wall were individually exposed to MMC fo...
PURPOSE: To compare concentrations of oxybutynin in the human bladder wall after either passive de...
Purpose We compared the relative permeability of upper urinary tract and bladder urothelium to mitom...
PURPOSE: To compare concentrations of oxybutynin in the human bladder wall after either passive deli...
The objectives of these investigations were: (a) to make a preliminary study to assess concentration...
The objectives of these investigations were: (a) to make a preliminary study to assess concentration...
The aim of this investigation was to establish an appropriate tissue pharmacokinetic model to compar...
The aim of this investigation was to establish an appropriate tissue pharmacokinetic model to compar...
Abstract PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly inc...
PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly increased trans...
ABSTRACT Purpose In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly incr...
PURPOSE: To compare concentrations of oxybutynin in the human bladder wall after either passive de...
Purpose We compared the relative permeability of upper urinary tract and bladder urothelium to mitom...
PURPOSE: To compare concentrations of oxybutynin in the human bladder wall after either passive deli...
The objectives of these investigations were: (a) to make a preliminary study to assess concentration...
The objectives of these investigations were: (a) to make a preliminary study to assess concentration...
The aim of this investigation was to establish an appropriate tissue pharmacokinetic model to compar...
The aim of this investigation was to establish an appropriate tissue pharmacokinetic model to compar...
Abstract PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly inc...
PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly increased trans...
ABSTRACT Purpose In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly incr...
PURPOSE: To compare concentrations of oxybutynin in the human bladder wall after either passive de...
Purpose We compared the relative permeability of upper urinary tract and bladder urothelium to mitom...
PURPOSE: To compare concentrations of oxybutynin in the human bladder wall after either passive deli...