TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1
- Cardellini, M
- Menghini, R
- Martelli, E
- Casagrande, V
- Marino, A
- Rizza, S
- Porzio, O
- Mauriello, A
- Solini, A
- Ippoliti, A
- Lauro, R
- Folli, F
- Federici, M
Publication date
October 2009
DOI Publisher
American Diabetes Association ISSN
0012-1797 Citation count (estimate)
91Abstract
Atherosclerosis is accelerated in subjects with type 2 diabetes by unknown mechanisms. We identified tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous inhibitor of A disintegrin and metalloprotease domain 17 (ADAM17) and other matrix metalloproteinases (MMPs), as a gene modifier for insulin resistance and vascular inflammation in mice. We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression
Add to ORKG