Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Chan, Melissa V.
Hayman, Melissa A.
Sivapalaratnam, Suthesh
Crescente, Marilena
Allan, Harriet E.
Edin, Matthew L.
Zeldin, Darryl C.
Milne, Ginger L.
Stephens, Jonathan
Greene, Daniel
Hanif, Moghees
O'Donnell, Valerie B.
Dong, Liang
Malkowski, Michael G.
Lentaigne, Claire
Wedderburn, Katherine
Stubbs, Matthew
Downes, Kate
Ouwehand, Willem H.
Turro, Ernest
NIHR BioResource
Hart, Daniel P.
Freson, Kathleen
Laffan, Michael A.
Warner, Timothy D.

May 2021

We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 i...

Nox-2 up-regulation and platelet activation: Novel insights.

Pastori, Daniele
Pignatelli, Pasquale
Carnevale, Roberto
Violi, Francesco

January 2015

Platelet activation is a key step in the onset of cardiovascular complications in patients affected ...

Relationship between platelet and urinary 8-Iso-PGF2α levels in subjects with different degrees of NOX2 regulation.

Roberto Carnevale
Luigi Iuliano
Cristina Nocella
Simona Bartimoccia
S. Trape
R. Russo
M.C. Gentile
Roberto Cangemi
Lorenzo Loffredo
Pasquale Pignatelli
Francesco Violi

January 2013

Background: Urinary 8-iso-PGF2α, a marker of oxidative stress, is influenced by the activation of NO...

Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction

Pignatelli, P
Carnevale, R
Di Santo, S
Bartimoccia, S
SANGUIGNI, VALERIO
Lenti, L
FINOCCHI, ANDREA
Mendolicchio, L
Soresina, A
Plebani, A
Violi, F.

February 2011

Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed t...

Inherited Human gp91(phox) Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction

Pasquale Pignatelli
Roberto Carnevale
S. Di Santo
S. Bartimoccia
V. Sanguigni
Luisa Lenti
Armando Finocchi
L. Mendolicchio
A.R. Soresina
A. Plebani
Francesco Violi

January 2011

OBJECT: Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is be...

Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia

Pignatelli, P
Carnevale, R
Cangemi, R
Loffredo, L
Sanguigni, V
Stefanutti, C
Basili, S
Violi, F

February 2010

The inhibition of oxidative stress is among the most relevant pleiotropic effects of statins. The me...

Hereditary deficiency of gp91phox is associated with enhanced arterial dilatation: Results of a multicenter study

Violi, Francesco
V., Sanguigni
Carnevale, Roberto
A., Plebani
Rossi, Paolo
A., Finocchi
C., Pignata
D., De Mattia
B., Martire
M. C., Pietrogrande
S., Martino
E., Gambineri
A. R., Soresina
Pignatelli, Pasquale
Martino, Francesco
Basili, Stefania
Loffredo, Lorenzo

January 2009

NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unclear. The ob...

Different Degrees of NADPH Oxidase 2 Regulation and In Vivo Platelet Activation: Lesson From Chronic Granulomatous Disease

Carnevale R.
Loffredo L.
Sanguigni V.
Plebani A.
Rossi P.
PIGNATA, CLAUDIO
Martire B.
Finocchi A.
Pietrogrande M. C.
Azzari C.
Soresina A. R.
Martino S.
CIRILLO, EMILIA
Martino F.
Pignatelli P.
Violi F.

January 2014

BACKGROUND: In vitro study showed that NADPH oxidase (NOx), the most important enzyme producing r...

Correspondence

Francesco Violi
Pasquale Pignatelli
I Clinica Medica
Prof Francesco Violi
I Clinica Medica

January 2013

There is a growing body of evidence to suggest that reactive oxidant species (ROS) including O2-, OH...

Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study

F. Violi
V. Sanguigni
R. Carnevale
A. Plebani
P. Rossi
A. Finocchi
C. Pignata
D. De Mattia
B. Martire
M.C. Pietrogrande
S. Martino
E. Gambineri
A.R. Soresina
P. Pignatelli
F. Martino
S. Basili
L. Loffredo

October 2009

AB BACKGROUND: NADPH oxidase is believed to modulate arterial tone, but its role in humans is still ...

Hereditary deficiency of gp91phox is associated with enhanced arterial dilatation.

Violi F.
Sanguigni V.
Carnevale R.
Plebani A.
Rossi P.
Finocchi A.
PIGNATA, CLAUDIO
De Mattia D.
Martire B.
Pietrogrande M. C.
Martino S.
Gambineri E.
Soresina A. R.
Pignatelli P.
Martino F.
Basili S.
Loffredo L.

January 2009

BACKGROUND: NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unc...

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

Emer M. Smyth
Francesco Violi
Domenico Praticò
Garret A. FitzGerald

June 1996

8-epi-Prostaglandin (PG) F2alpha may be formed by cyclooxygenases 1 and 2 or by a free radical catal...

Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation

Aldrovandi, Maceler
Hammond, Victoria Jayne
Podmore, Helen
Hornshaw, Martin
Clark, Stephen Robert
Marnett, Lawrence J.
Slatter, David
Murphy, Robert C.
Collins, Peter William
O'Donnell, Valerie Bridget

Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in ...

Hereditary Deficiency of gp91(phox) Is Associated With Enhanced Arterial Dilatation Results of a Multicenter Study

Violi, F
Carnevale, R
Plebani, A
Pignata, C
De Mattia, D
Martire, B
Pietrogrande, MC
Martino, S
Gambineri, E
Soresina, AR
Pignatelli, P
Martino, F
Basili, S
Loffredo, L.
SANGUIGNI, VALERIO
ROSSI, PAOLO
FINOCCHI, ANDREA

January 2009

Background-NADPH oxidase is believed to modulate arterial tone, but its role in humans is still uncl...

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis

Palma-Barqueros, Verónica
Crescente, Marilena
Morena, María Eugenia de la
Chan, Melissa V.
Almarza, Elena
Revilla, Nuria
Bohdan, Natalia
Miñano, Antonia
Padilla, Jose
Allan, Harriet E.
Maffucci, Tania
Edin, Matthew L.
Zeldin, Darryl C.
Mesa-Nuñez, Cristina
Damian, Carlos
Marín-Quilez, Ana
Benito, Rocío
Martínez-Martínez, Irene
Bermejo, Nuria
Casas-Aviles, Ignacio
Rodriguez-Alén, Agustín
González-Porras, José R.
Hernández, Jesús M.
Vicente, Vicente
Corral, J.
Lozano, María L.
Warner, Timothy D.
Bastida, José María
Rivera, José

February 2022

During platelet activation, arachidonic acid (AA) is released from membrane phospholipids and metabo...

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Chan, Melissa V.
Hayman, Melissa A.
Sivapalaratnam, Suthesh
Crescente, Marilena
Allan, Harriet E.
Edin, Matthew L.
Zeldin, Darryl C.
Milne, Ginger L.
Stephens, Jonathan
Greene, Daniel
Hanif, Moghees
O'Donnell, Valerie B.
Dong, Liang
Malkowski, Michael G.
Lentaigne, Claire
Wedderburn, Katherine
Stubbs, Matthew
Downes, Kate
Ouwehand, Willem H.
Turro, Ernest
NIHR BioResource
Hart, Daniel P.
Freson, Kathleen
Laffan, Michael A.
Warner, Timothy D.

May 2021

We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 i...

Nox-2 up-regulation and platelet activation: Novel insights.

Pastori, Daniele
Pignatelli, Pasquale
Carnevale, Roberto
Violi, Francesco

January 2015

Platelet activation is a key step in the onset of cardiovascular complications in patients affected ...

Relationship between platelet and urinary 8-Iso-PGF2α levels in subjects with different degrees of NOX2 regulation.

Roberto Carnevale
Luigi Iuliano
Cristina Nocella
Simona Bartimoccia
S. Trape
R. Russo
M.C. Gentile
Roberto Cangemi
Lorenzo Loffredo
Pasquale Pignatelli
Francesco Violi

January 2013

Background: Urinary 8-iso-PGF2α, a marker of oxidative stress, is influenced by the activation of NO...

Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction

Pignatelli, P
Carnevale, R
Di Santo, S
Bartimoccia, S
SANGUIGNI, VALERIO
Lenti, L
FINOCCHI, ANDREA
Mendolicchio, L
Soresina, A
Plebani, A
Violi, F.

February 2011

Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed t...

Inherited Human gp91(phox) Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction

Pasquale Pignatelli
Roberto Carnevale
S. Di Santo
S. Bartimoccia
V. Sanguigni
Luisa Lenti
Armando Finocchi
L. Mendolicchio
A.R. Soresina
A. Plebani
Francesco Violi

January 2011

OBJECT: Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is be...

Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia

Pignatelli, P
Carnevale, R
Cangemi, R
Loffredo, L
Sanguigni, V
Stefanutti, C
Basili, S
Violi, F

February 2010

The inhibition of oxidative stress is among the most relevant pleiotropic effects of statins. The me...

Hereditary deficiency of gp91phox is associated with enhanced arterial dilatation: Results of a multicenter study

Violi, Francesco
V., Sanguigni
Carnevale, Roberto
A., Plebani
Rossi, Paolo
A., Finocchi
C., Pignata
D., De Mattia
B., Martire
M. C., Pietrogrande
S., Martino
E., Gambineri
A. R., Soresina
Pignatelli, Pasquale
Martino, Francesco
Basili, Stefania
Loffredo, Lorenzo

January 2009

NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unclear. The ob...

Different Degrees of NADPH Oxidase 2 Regulation and In Vivo Platelet Activation: Lesson From Chronic Granulomatous Disease

Carnevale R.
Loffredo L.
Sanguigni V.
Plebani A.
Rossi P.
PIGNATA, CLAUDIO
Martire B.
Finocchi A.
Pietrogrande M. C.
Azzari C.
Soresina A. R.
Martino S.
CIRILLO, EMILIA
Martino F.
Pignatelli P.
Violi F.

January 2014

BACKGROUND: In vitro study showed that NADPH oxidase (NOx), the most important enzyme producing r...

Correspondence

Francesco Violi
Pasquale Pignatelli
I Clinica Medica
Prof Francesco Violi
I Clinica Medica

January 2013

There is a growing body of evidence to suggest that reactive oxidant species (ROS) including O2-, OH...

Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study

F. Violi
V. Sanguigni
R. Carnevale
A. Plebani
P. Rossi
A. Finocchi
C. Pignata
D. De Mattia
B. Martire
M.C. Pietrogrande
S. Martino
E. Gambineri
A.R. Soresina
P. Pignatelli
F. Martino
S. Basili
L. Loffredo

October 2009

AB BACKGROUND: NADPH oxidase is believed to modulate arterial tone, but its role in humans is still ...

Hereditary deficiency of gp91phox is associated with enhanced arterial dilatation.

Violi F.
Sanguigni V.
Carnevale R.
Plebani A.
Rossi P.
Finocchi A.
PIGNATA, CLAUDIO
De Mattia D.
Martire B.
Pietrogrande M. C.
Martino S.
Gambineri E.
Soresina A. R.
Pignatelli P.
Martino F.
Basili S.
Loffredo L.

January 2009

BACKGROUND: NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unc...

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

Emer M. Smyth
Francesco Violi
Domenico Praticò
Garret A. FitzGerald

June 1996

8-epi-Prostaglandin (PG) F2alpha may be formed by cyclooxygenases 1 and 2 or by a free radical catal...

Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation

Aldrovandi, Maceler
Hammond, Victoria Jayne
Podmore, Helen
Hornshaw, Martin
Clark, Stephen Robert
Marnett, Lawrence J.
Slatter, David
Murphy, Robert C.
Collins, Peter William
O'Donnell, Valerie Bridget

Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in ...

Hereditary Deficiency of gp91(phox) Is Associated With Enhanced Arterial Dilatation Results of a Multicenter Study

Violi, F
Carnevale, R
Plebani, A
Pignata, C
De Mattia, D
Martire, B
Pietrogrande, MC
Martino, S
Gambineri, E
Soresina, AR
Pignatelli, P
Martino, F
Basili, S
Loffredo, L.
SANGUIGNI, VALERIO
ROSSI, PAOLO
FINOCCHI, ANDREA

January 2009

Background-NADPH oxidase is believed to modulate arterial tone, but its role in humans is still uncl...

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis

Palma-Barqueros, Verónica
Crescente, Marilena
Morena, María Eugenia de la
Chan, Melissa V.
Almarza, Elena
Revilla, Nuria
Bohdan, Natalia
Miñano, Antonia
Padilla, Jose
Allan, Harriet E.
Maffucci, Tania
Edin, Matthew L.
Zeldin, Darryl C.
Mesa-Nuñez, Cristina
Damian, Carlos
Marín-Quilez, Ana
Benito, Rocío
Martínez-Martínez, Irene
Bermejo, Nuria
Casas-Aviles, Ignacio
Rodriguez-Alén, Agustín
González-Porras, José R.
Hernández, Jesús M.
Vicente, Vicente
Corral, J.
Lozano, María L.
Warner, Timothy D.
Bastida, José María
Rivera, José

February 2022

During platelet activation, arachidonic acid (AA) is released from membrane phospholipids and metabo...

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Chan, Melissa V.
Hayman, Melissa A.
Sivapalaratnam, Suthesh
Crescente, Marilena
Allan, Harriet E.
Edin, Matthew L.
Zeldin, Darryl C.
Milne, Ginger L.
Stephens, Jonathan
Greene, Daniel
Hanif, Moghees
O'Donnell, Valerie B.
Dong, Liang
Malkowski, Michael G.
Lentaigne, Claire
Wedderburn, Katherine
Stubbs, Matthew
Downes, Kate
Ouwehand, Willem H.
Turro, Ernest
NIHR BioResource
Hart, Daniel P.
Freson, Kathleen
Laffan, Michael A.
Warner, Timothy D.

May 2021

We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 i...

Nox-2 up-regulation and platelet activation: Novel insights.

Pastori, Daniele
Pignatelli, Pasquale
Carnevale, Roberto
Violi, Francesco

January 2015

Platelet activation is a key step in the onset of cardiovascular complications in patients affected ...

Relationship between platelet and urinary 8-Iso-PGF2α levels in subjects with different degrees of NOX2 regulation.

Roberto Carnevale
Luigi Iuliano
Cristina Nocella
Simona Bartimoccia
S. Trape
R. Russo
M.C. Gentile
Roberto Cangemi
Lorenzo Loffredo
Pasquale Pignatelli
Francesco Violi

January 2013

Background: Urinary 8-iso-PGF2α, a marker of oxidative stress, is influenced by the activation of NO...

Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction

Abstract

Extracted data

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