Synapses are ultrastructural sites for memory storage in brain, and synaptic damage is the best pathologic correlate of cognitive decline in Alzheimer's disease (AD). Post-translational hyperphosphorylation, enzyme-mediated truncation, conformational modifications, and aggregation of tau protein into neurofibrillary tangles (NFTs) are hallmarks for a heterogeneous group of neurodegenerative disorders, so-called tauopathies. AD is a secondary tauopathy since it is pathologically distinguished by the presence of amyloid-beta (Abeta)-containing senile plaques and the presence of tau-positive NFTs in the neocortex and hippocampus. Here, we report that a 20-22 kDa NH2-truncated tau fragment is largely enriched in human mitochondria from cryopres...
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the patho...
AbstractThe energy demand and calcium buffering requirements of the brain are met by the high number...
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition, impairments...
Synapses are ultrastructural sites for memory storage in brain, and synaptic damage is the best path...
Functional as well as structural alterations in mitochondria size, shape and distribution are precip...
Although amyloid beta (A beta) peptide can promote tau pathology and its toxicity is concurrently ta...
Although amyloid beta (A beta) peptide can promote tau pathology and its toxicity is concurrently ta...
Although amyloid beta (A\u3b2) peptide can promote tau pathology and its toxicity is concurrently ta...
The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF)...
Corrigendum of: Functional as well as structural alterations in mitochondria size, shape and distrib...
Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzh...
Tau is an essential protein that physiologically promotes the assembly and stabilization of microtub...
Biochemical modifications of tau proteins have been proposed to be among the earliest neurobiologica...
Biochemical modifications of tau proteins have been proposed to be among the earliest neurobiologica...
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the patho...
AbstractThe energy demand and calcium buffering requirements of the brain are met by the high number...
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition, impairments...
Synapses are ultrastructural sites for memory storage in brain, and synaptic damage is the best path...
Functional as well as structural alterations in mitochondria size, shape and distribution are precip...
Although amyloid beta (A beta) peptide can promote tau pathology and its toxicity is concurrently ta...
Although amyloid beta (A beta) peptide can promote tau pathology and its toxicity is concurrently ta...
Although amyloid beta (A\u3b2) peptide can promote tau pathology and its toxicity is concurrently ta...
The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF)...
Corrigendum of: Functional as well as structural alterations in mitochondria size, shape and distrib...
Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzh...
Tau is an essential protein that physiologically promotes the assembly and stabilization of microtub...
Biochemical modifications of tau proteins have been proposed to be among the earliest neurobiologica...
Biochemical modifications of tau proteins have been proposed to be among the earliest neurobiologica...
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the patho...
AbstractThe energy demand and calcium buffering requirements of the brain are met by the high number...
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition, impairments...