Computer Aided Diagnosis for Anti-Nuclear Antibodies HEp-2 Images: Progress and Challenges

The Anti-Nuclear Antibodies (ANA) test using Human Epithelial (HEp-2) cells has been the gold standard to identify the presence of Connective Tissue Diseases (CTD) such us Systemic Lupus Erythomatus (SLE). As the ANA test is time consuming, labour intensive and subjective, there has been an on-going effort to develop image-based Computer Aided Diagnosis (CAD) systems. This paper discusses the current progress and challenges in this field and will highlight areas which require more attention