Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment; however, patients have increasingly shown resistance and sensitivity to the high toxicity of these drugs, and identification of novel targeted therapies is therefore required. To determine whether nemorosone, a polycyclic polyisoprenylated benzophenone isolated from floral resins of Clusia rosea Jacq. and Cuban propolis samples, exerts anticancer effects on human breast cancer cells, estrogen receptor positive (ERα+) MCF-7 and estrogen receptor negative (ERα–) MDA-MB-231 and LNCaP cells were used. Cells were treated with nemorosone alone or in association with 17β-estradiol (E2) or an ER antagonist, ICI 182,780, a selective ER downregulator that completely...
In the present study, we evaluated the individual and combined effects of environmental estrogens an...
Abstract Background Our previous studies demonstrated that growth and migration of medulloblastoma (...
The aim of this study was to examine the estrogen-like effects of gentiopicroside, macelignan, γ-man...
Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment; however, patie...
Background: Brown propolis is the major type of propolis found in Cuba; its principal component is n...
Currently, a wide range of research involving natural products is focused on the discovery of new dr...
Brown Cuban propolis (BCP) is the major type of propolis in Cuba; its chemical composition is exclus...
Propolis is a natural product obtained from bees, used since ancient times for its multiple pharmaco...
Anemone nemorosa is part of the Ranunculaceae genus Anemone (order Ranunculales) which comprises mor...
Pancreatic cancer is one of the leading cancer-related causes of death in the western world with an ...
Pancreatic cancer is one of the leading cancer-related causes of death in the western world with an ...
Estrogen and estrogen receptor (ER)-mediated signaling pathways play important roles in the etiology...
The growth modulating effects of the ovarian steroid hormones 17β-estradiol (E2) and progesterone (P...
Cutaneous melanoma is one of the most frequent and aggressive forms of malignant skin cancer. In agr...
Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and pharmacolo...
In the present study, we evaluated the individual and combined effects of environmental estrogens an...
Abstract Background Our previous studies demonstrated that growth and migration of medulloblastoma (...
The aim of this study was to examine the estrogen-like effects of gentiopicroside, macelignan, γ-man...
Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment; however, patie...
Background: Brown propolis is the major type of propolis found in Cuba; its principal component is n...
Currently, a wide range of research involving natural products is focused on the discovery of new dr...
Brown Cuban propolis (BCP) is the major type of propolis in Cuba; its chemical composition is exclus...
Propolis is a natural product obtained from bees, used since ancient times for its multiple pharmaco...
Anemone nemorosa is part of the Ranunculaceae genus Anemone (order Ranunculales) which comprises mor...
Pancreatic cancer is one of the leading cancer-related causes of death in the western world with an ...
Pancreatic cancer is one of the leading cancer-related causes of death in the western world with an ...
Estrogen and estrogen receptor (ER)-mediated signaling pathways play important roles in the etiology...
The growth modulating effects of the ovarian steroid hormones 17β-estradiol (E2) and progesterone (P...
Cutaneous melanoma is one of the most frequent and aggressive forms of malignant skin cancer. In agr...
Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and pharmacolo...
In the present study, we evaluated the individual and combined effects of environmental estrogens an...
Abstract Background Our previous studies demonstrated that growth and migration of medulloblastoma (...
The aim of this study was to examine the estrogen-like effects of gentiopicroside, macelignan, γ-man...