Add to ORKGGilbert syndrome (GS) is an inherited form of chronic mild unconjugated hyperbilirubinemia (1)(2)(3), although many patients do not have a clear family history (4). Hepatic glucuronidation of bilirubin is catalyzed by isoenzyme 1A1 of UDP-glucuronosyl transferase (UGT1A1). The majority of GS subjects were found to be homozygous for an extra TA in the TATA-box in the promoter region of UGT1A1 (5)(6)(7). Transcription of the (TA)7 allele is reduced by at least 70% compared with the wild-type (TA)6 allele. Because bilirubin UGT1A1 is the only enzyme with substantial bilirubin glucuronidating activity in humans (8), the presence of this extra TA in both alleles can explain the impaired conjugation of bilirubin found in Caucasoid GS patients (6)
Although in Gilbert's syndrome (GS), bilirubin glucuronidation is impaired due to an extra TA in the...
The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5'-diphosphoglucose...
Hemolysis may contribute to hyperbilirubinemia in Gilbert's syndrome. The authors examined blood car...
Background. People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the...
Background. People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the...
Recent research has shown that congenital nonhemolytic low grade hyperbilirubinemias in patients wit...
Background and Objective. Gilbert's syndrome, a chronic non-hemolytic unconjugated hyperbilirubinemi...
Background/Aims: Gilbert's syndrome is a benign form of a deficiency in bilirubin glucuronidation. I...
The Gilbert syndrome is a benign form of unconjugated hyperbilirubinemia, mainly associated with alt...
BACKGROUND AND OBJECTIVE: Gilbert's syndrome, a chronic non-hemolytic unconjugated hyperbilirubinem...
We evaluated the effect of Gilbert's syndrome, the most common defect of bilirubin conjugation, on t...
UGT1A1 gene variations in individuals with and without clinical diagnosis of Gilbert Syndrome Bil...
Hepatic glucuronization of insoluble bilirubin is catalyzed by isoenzyme 1A1 of UDP-glucuronosyltran...
Gilbert syndrome (GS, OMIM 606785) is an autosomal recessive condition characterized by unconjugated...
Gilbert syndrome (GS, OMIM 606785) is an autosomal recessive condition characterized by unconjugated...
Although in Gilbert's syndrome (GS), bilirubin glucuronidation is impaired due to an extra TA in the...
The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5'-diphosphoglucose...
Hemolysis may contribute to hyperbilirubinemia in Gilbert's syndrome. The authors examined blood car...
Background. People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the...
Background. People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the...
Recent research has shown that congenital nonhemolytic low grade hyperbilirubinemias in patients wit...
Background and Objective. Gilbert's syndrome, a chronic non-hemolytic unconjugated hyperbilirubinemi...
Background/Aims: Gilbert's syndrome is a benign form of a deficiency in bilirubin glucuronidation. I...
The Gilbert syndrome is a benign form of unconjugated hyperbilirubinemia, mainly associated with alt...
BACKGROUND AND OBJECTIVE: Gilbert's syndrome, a chronic non-hemolytic unconjugated hyperbilirubinem...
We evaluated the effect of Gilbert's syndrome, the most common defect of bilirubin conjugation, on t...
UGT1A1 gene variations in individuals with and without clinical diagnosis of Gilbert Syndrome Bil...
Hepatic glucuronization of insoluble bilirubin is catalyzed by isoenzyme 1A1 of UDP-glucuronosyltran...
Gilbert syndrome (GS, OMIM 606785) is an autosomal recessive condition characterized by unconjugated...
Gilbert syndrome (GS, OMIM 606785) is an autosomal recessive condition characterized by unconjugated...
Although in Gilbert's syndrome (GS), bilirubin glucuronidation is impaired due to an extra TA in the...
The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5'-diphosphoglucose...
Hemolysis may contribute to hyperbilirubinemia in Gilbert's syndrome. The authors examined blood car...