a-Methylenelactones have received much attention due to the biological activity exhibited by natural products containing this structural moiety [1]. Cytotoxic, anti-inflammatory, phytotoxic, allergenic and antimicrobial properties are shown not only by highly functionalized, complex sesquiterpene lactones but also simple representatives were studied for their biological effects. Besides, compared to normal human tissues, many common human cancers, express high levels of fatty acid synthase (FAS), the primary enzyme responsible for the synthesis of fatty acids. This differential expression of FAS between normal tissues and cancer has led to the notion that FAS is a target for anticancer drug development [2]. A new series of a-methylene-g.but...
As a continuation of our studies aimed at the development of a new cytostatic agent derived from an ...
Liposarcomas (LS) are mesenchymal tumors that can recur after surgical resection and often do not re...
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside...
The \u3b1-methylene-\u3b3-butyrolactone skeleton is part of many natural products with remarkable bi...
Reported herein are the synthesis and biological evaluation of α-methylene-γ-butyrolactones. Using “...
The synthesis of a series of \u3b1-methylene-\u3b3-butyrolactones (compounds 4a, 4b, 6\u201312, 16, ...
Sesquiterpene lactones are plant-derived compounds that have been shown to possess significant activ...
The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group i...
Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory acti...
The present study involves the synthesis of macrocyclic lactones by the esterification of unsaturate...
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Che...
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Che...
Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers...
Oleanolic acid (1), ursolic acid (2), hederagenin (3), betulinol (4), betulinic acid (5), and glycyr...
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside...
As a continuation of our studies aimed at the development of a new cytostatic agent derived from an ...
Liposarcomas (LS) are mesenchymal tumors that can recur after surgical resection and often do not re...
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside...
The \u3b1-methylene-\u3b3-butyrolactone skeleton is part of many natural products with remarkable bi...
Reported herein are the synthesis and biological evaluation of α-methylene-γ-butyrolactones. Using “...
The synthesis of a series of \u3b1-methylene-\u3b3-butyrolactones (compounds 4a, 4b, 6\u201312, 16, ...
Sesquiterpene lactones are plant-derived compounds that have been shown to possess significant activ...
The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group i...
Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory acti...
The present study involves the synthesis of macrocyclic lactones by the esterification of unsaturate...
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Che...
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Che...
Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers...
Oleanolic acid (1), ursolic acid (2), hederagenin (3), betulinol (4), betulinic acid (5), and glycyr...
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside...
As a continuation of our studies aimed at the development of a new cytostatic agent derived from an ...
Liposarcomas (LS) are mesenchymal tumors that can recur after surgical resection and often do not re...
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside...