BACKGROUND & AIMS: We tested the effects of branched chain-enriched, aromatic-deficient amino acids with insulin to correct the altered protein turnover as well as phenylalanine (Phe) and leucine (Leu) rate of appearance in compensated cirrhotics and controls. METHODS: Phe and Leu tracers were infused both before and following intravenous amino acid administration with insulin and euglycemic clamp. RESULTS: In cirrhosis, fasting whole-body protein synthesis and protein degradation were normal; Phe rate of appearance was greater (P<0.05), whereas Leu rate of appearance/Phe rate of appearance ratio was approximately 35% less than in controls (P<0.001). Following the infusion, protein synthesis did not increase (+1% +/ 5% [NS] vs. +21% +/-...
International audienceBACKGROUND: Hepatic glucose uptake is enhanced by the portal delivery of gluco...
BACKGROUND/AIMS: An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to...
Background: This study aimed to investigate the long-term effects of branched-chain amino acids (BCA...
Summary: Changes in amino acid concentrations in plasma during a 100 g oral glucose tolerance test w...
Introduction and objectives: The potential benefits of branched-chain amino acids (BCAAs) in cirrhos...
To investigate body protein turnover and the pathogenesis of increased concentration of plasma pheny...
Background & aims: We investigated possible involvements of bile acids (BA) and leptin in hepatogeno...
BACKGROUND ; AIMS: The role of oral supplementation with branched-chain amino acids (BCAA) in adva...
We explored the mechanism(s) of increased aromatic amino acids concentrations in liver cirrhosis usi...
The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been w...
The blood levels of amino acids, ammonia and pancreatic hormones following the intragastric and intr...
SUMMARY Thirty seven patients with established cirrhosis of the liver were subjected to measurement ...
BACKGROUND & AIMS: Although metabolic acidosis stimulates protein catabolism, its effects on spl...
Background and aims: Intense systemic inflammatory responses and the existence of organ failures are...
PURPOSE OF REVIEW: Phenylalanine conversion to tyrosine (i.e., 'hydroxylation') is the first irrever...
International audienceBACKGROUND: Hepatic glucose uptake is enhanced by the portal delivery of gluco...
BACKGROUND/AIMS: An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to...
Background: This study aimed to investigate the long-term effects of branched-chain amino acids (BCA...
Summary: Changes in amino acid concentrations in plasma during a 100 g oral glucose tolerance test w...
Introduction and objectives: The potential benefits of branched-chain amino acids (BCAAs) in cirrhos...
To investigate body protein turnover and the pathogenesis of increased concentration of plasma pheny...
Background & aims: We investigated possible involvements of bile acids (BA) and leptin in hepatogeno...
BACKGROUND ; AIMS: The role of oral supplementation with branched-chain amino acids (BCAA) in adva...
We explored the mechanism(s) of increased aromatic amino acids concentrations in liver cirrhosis usi...
The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been w...
The blood levels of amino acids, ammonia and pancreatic hormones following the intragastric and intr...
SUMMARY Thirty seven patients with established cirrhosis of the liver were subjected to measurement ...
BACKGROUND & AIMS: Although metabolic acidosis stimulates protein catabolism, its effects on spl...
Background and aims: Intense systemic inflammatory responses and the existence of organ failures are...
PURPOSE OF REVIEW: Phenylalanine conversion to tyrosine (i.e., 'hydroxylation') is the first irrever...
International audienceBACKGROUND: Hepatic glucose uptake is enhanced by the portal delivery of gluco...
BACKGROUND/AIMS: An upper gastrointestinal (GI) bleed in cirrhotic patients has been hypothesised to...
Background: This study aimed to investigate the long-term effects of branched-chain amino acids (BCA...