HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

Comar, Manola
Grasso, D
Dal Molin, G
Zocconi, E
Campello, Cesare

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Publication date

January 2010

DOI

10.1016/j.ijporl.2009.10.008

Publisher

Elsevier BV

ISSN

0165-5876

Citation count (estimate)

Abstract

OBJECTIVE: Human herpes virus 6 (HHV-6), the agent of a self-limiting exanthematic disease in childhood, persists in a silent state in the secondary lymphoid organs and the reactivation is characterized by HHV-6-induced inflammatory cytokines. This study investigates the possible etiological role of HHV-6 in children affected by tonsil and adenoid hypertrophy. METHODS: 55 tonsils, 80 adenoids fresh tissues and 74 blood samples were collected from 80 children (mean age 4.8 years, 43.5% female) undergoing elective tonsillectomy and/or adenoidectomy for tissue hypertrophy. Moreover, patients with <5 years old documented upper airway recurrent infections not related to relapsing of acute tonsillitis. Specific IgG antibodies and virus detection...

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HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

Abstract

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HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

Abstract

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