PMAP-36 is a cathelicidin-derived host defence peptide originally deduced by a transcript from pig bone marrow RNA. The expression of the propeptide in leukocytes, and the structure, antimicrobial activity, and mechanism of action of the mature peptide were investigated. The proform is stored as a dimeric precursor of 38 kDa formed by a dimerization site at its C-terminal cysteine residue; it is likely that the mature peptide is dimeric when released. Monomeric and dimeric forms of PMAP-36 were chemically synthesized and their activity compared. Both forms assumed an amphipathic a-helical conformation and exhibited a potent and rapid microbicidal activity against a wide spectrum of microorganisms, mediated by their ability to permeabilize t...
Host defense peptides (HDPs), such as cathelicidins, are small, cationic, amphipathic peptides and r...
PMAP-23 is a member of the cathelicidin family derived from pig myeloid cells and has potent antimic...
SummaryThe structure and function of the synthetic innate defense regulator peptide 1018 was investi...
Abstract Cathelicidins, a family of host defence peptides in vertebrates, play an important role in ...
Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimic...
<div><p>Antimicrobial peptides (AMPs), which present in the non-specific immune system of organism, ...
Antimicrobial peptides (AMPs), which present in the non-specific immune system of organism, are amon...
A molecular biological approach, based on preproregion homology in the precursors of several diverse...
The increasing resistance of bacteria to conventional antibiotics has encouraged strong efforts to d...
Cathelicidins are a recently discovered family of effector molecules in innate immunity. In the past...
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of peptides in h...
Cathelicidins constitute potent antimicrobial peptides characterized by a high cationic charge that ...
AbstractHost defense antimicrobial peptides are key components of human innate immunity that plays a...
Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all types of v...
Cathelicidins are a family of myeloid antimicrobial peptide precursors that have been identified in ...
Host defense peptides (HDPs), such as cathelicidins, are small, cationic, amphipathic peptides and r...
PMAP-23 is a member of the cathelicidin family derived from pig myeloid cells and has potent antimic...
SummaryThe structure and function of the synthetic innate defense regulator peptide 1018 was investi...
Abstract Cathelicidins, a family of host defence peptides in vertebrates, play an important role in ...
Host defense peptides (HDPs) play a pivotal role in innate immunity and have, in addition to antimic...
<div><p>Antimicrobial peptides (AMPs), which present in the non-specific immune system of organism, ...
Antimicrobial peptides (AMPs), which present in the non-specific immune system of organism, are amon...
A molecular biological approach, based on preproregion homology in the precursors of several diverse...
The increasing resistance of bacteria to conventional antibiotics has encouraged strong efforts to d...
Cathelicidins are a recently discovered family of effector molecules in innate immunity. In the past...
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of peptides in h...
Cathelicidins constitute potent antimicrobial peptides characterized by a high cationic charge that ...
AbstractHost defense antimicrobial peptides are key components of human innate immunity that plays a...
Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all types of v...
Cathelicidins are a family of myeloid antimicrobial peptide precursors that have been identified in ...
Host defense peptides (HDPs), such as cathelicidins, are small, cationic, amphipathic peptides and r...
PMAP-23 is a member of the cathelicidin family derived from pig myeloid cells and has potent antimic...
SummaryThe structure and function of the synthetic innate defense regulator peptide 1018 was investi...