A comprehensive, high-resolution genomic transcript map of human skeletal muscle.
- BORTOLUZZI S.
- RAMPOLDI L.
- SIMIONATI B.
- ZIMBELLO R.
- BARBON A.
- D'ALESSI F.
- TISO N.
- PALLAVICINI A.
- TOPPO S.
- CANNATA N.
- VALLE G.
- LANFRANCHI G.
- DANIELI GA.
DOIAbstract
We present the Human Muscle Gene Map (HMGM), the first comprehensive and updated high-resolution expression map of human skeletal muscle. The 1078 entries of the map were obtained by merging data retrieved from UniGene with the RH mapping information on 46 novel muscle transcripts, which showed no similarity to any known sequence. In the map, distances are expressed in megabase pairs. About one-quarter of the map entries represents putative novel genes. Genes known to be specifically expressed in muscle account for <4% of the total. The genomic distribution of the map entries confirmed the previous finding that muscle genes are selectively concentrated in chromosomes 17, 19, and X. Five chromosomal regions are suspected to have a significan...
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