In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field
The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of mod...
This book compiles recent research on the modification of nucleic acids. It covers backbone modifica...
Specific target binding and stability in diverse biological media is of crucial importance for appli...
In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and...
AbstractOligonucleotide-peptide conjugates have several applications, including their potential use ...
Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therap...
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy...
The underlying idea of oligonucleotide conjugates is to provide oligonucleotide with some novel prop...
Short DNA or RNA oligonucleotides have tremendous potential as therapeutic agents. Because of their ...
Tumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide...
Oligonucleotide therapeutics show great potential for gene-specific therapy of a wide variety of dis...
Nucleic acid-based therapeutics that regulate gene expression have been developed towards clinical u...
International audienceOligonucleotide-based agents have the potential to treat or cure almost any di...
Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen...
Nucleic acid-based therapeutics that regulate gene expression have been developed towards clinical u...
The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of mod...
This book compiles recent research on the modification of nucleic acids. It covers backbone modifica...
Specific target binding and stability in diverse biological media is of crucial importance for appli...
In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and...
AbstractOligonucleotide-peptide conjugates have several applications, including their potential use ...
Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therap...
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy...
The underlying idea of oligonucleotide conjugates is to provide oligonucleotide with some novel prop...
Short DNA or RNA oligonucleotides have tremendous potential as therapeutic agents. Because of their ...
Tumor-specific accumulation of antisense therapeutics: The conjugation of a receptor-binding peptide...
Oligonucleotide therapeutics show great potential for gene-specific therapy of a wide variety of dis...
Nucleic acid-based therapeutics that regulate gene expression have been developed towards clinical u...
International audienceOligonucleotide-based agents have the potential to treat or cure almost any di...
Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen...
Nucleic acid-based therapeutics that regulate gene expression have been developed towards clinical u...
The advent of rapid and efficient methods of oligonucleotide synthesis has allowed the design of mod...
This book compiles recent research on the modification of nucleic acids. It covers backbone modifica...
Specific target binding and stability in diverse biological media is of crucial importance for appli...
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