A membrane system consisting of poly(acrylic acid)-grafted porous cellulose film and glucose oxidase was synthesized for insulin delivery in response to glucose concentration. The principle of this system is based on the conformational change of the graft chains in response to pH. At neutral pH in the absence of glucose, the carboxylate groups of poly(acrylic acid) grafts were negatively charged. Repulsion between negative charges made the polymer chains extend and closed the pores of the membrane. Glucose oxidase catalyzed the oxidation of glucose to gluconic acid which, in turn, protonated the carboxylate groups on the graft membrane. A reduced electrostatic repulsion between the poly(acrylic acid) side chains made the graft chains coil-l...
ABSTRACT: A new glucose-responsive formulation for self-regulated insulin delivery was constructed b...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, February,...
dissertationThe development of a self-regulating insulin delivery system to modulate insulin release...
Two kinds of glucose-sensitive insulin-releasing systems were developed. The first system is based o...
Two weak poly(acid)s, poly(acrylic acid) (PAA) and poly(N-acryloyl-glycine) (P1), were graft-copolym...
The insulin permeation of poly(N-acryloyl-glycine), P1, was studied using a porous cellulose membran...
Self-regulated drug delivery systems (DDS) are potential alternative to the conventional method of i...
312 ABSTRACT: A novel polymer system sensitive to glucose concentration has been studied as a can-di...
Biodegradable and pH-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synt...
Smart insulin delivery systems now play essential roles in diabetes treatment, whereas most existing...
One of the most effective treatments for diabetes is to design a glucose-regulated insulin (INS) del...
Development of modulated insulin delivery devices is important for the control of diabetes because s...
Diabetes mellitus is a chronic illness manifested by improper blood glucose management, affecting ov...
The recovery of diminished or lost regulatory functions of physiological systems drives important re...
Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance h...
ABSTRACT: A new glucose-responsive formulation for self-regulated insulin delivery was constructed b...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, February,...
dissertationThe development of a self-regulating insulin delivery system to modulate insulin release...
Two kinds of glucose-sensitive insulin-releasing systems were developed. The first system is based o...
Two weak poly(acid)s, poly(acrylic acid) (PAA) and poly(N-acryloyl-glycine) (P1), were graft-copolym...
The insulin permeation of poly(N-acryloyl-glycine), P1, was studied using a porous cellulose membran...
Self-regulated drug delivery systems (DDS) are potential alternative to the conventional method of i...
312 ABSTRACT: A novel polymer system sensitive to glucose concentration has been studied as a can-di...
Biodegradable and pH-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synt...
Smart insulin delivery systems now play essential roles in diabetes treatment, whereas most existing...
One of the most effective treatments for diabetes is to design a glucose-regulated insulin (INS) del...
Development of modulated insulin delivery devices is important for the control of diabetes because s...
Diabetes mellitus is a chronic illness manifested by improper blood glucose management, affecting ov...
The recovery of diminished or lost regulatory functions of physiological systems drives important re...
Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance h...
ABSTRACT: A new glucose-responsive formulation for self-regulated insulin delivery was constructed b...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, February,...
dissertationThe development of a self-regulating insulin delivery system to modulate insulin release...