Add to ORKGTitle compds. [I; X = CH, N; R = H, alkylthio, alkylamino, cycloalkyl, cycloalkylthio, cycloalkylamino, alkyl, etc.; R1 = NHR6, N(R6)2; R6 = alkyl, cycloalkyl, pyrrolidinyl, morpholino, hexahydroazepinyl, (substituted) (hetero)aryl(alkyl)], were prepd. Thus, title compd. (II) (multistep prepn. outlined) after 48 h reduced cellular viability of SaOS-2 cells to 15.1% of controls
The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrim...
We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biologica...
Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcom...
Title compds. [I; X = CH, N; R = H, alkylthio, alkylamino, cycloalkyl, cycloalkylthio, cycloalkylami...
4-\u200bAmino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyrimidine and pyrrolo[2,\u200b3-\u...
Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...
Title compds. [I; Y = SO2, NR; R = H, alkyl; X = H, alkyl, CO, SO, SO2, COR2, SOR2, SO2R2; R2 = H, a...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine derivatives, belonging...
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-f...
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-f...
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. C...
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffol...
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were syn...
The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrim...
We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biologica...
Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcom...
Title compds. [I; X = CH, N; R = H, alkylthio, alkylamino, cycloalkyl, cycloalkylthio, cycloalkylami...
4-\u200bAmino-\u200bsubstituted pyrazolo[3,\u200b4-\u200bd]\u200bpyrimidine and pyrrolo[2,\u200b3-\u...
Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...
Title compds. [I; Y = SO2, NR; R = H, alkyl; X = H, alkyl, CO, SO, SO2, COR2, SOR2, SO2R2; R2 = H, a...
The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine derivatives, belonging...
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-f...
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-f...
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. C...
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffol...
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were syn...
The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrim...
We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biologica...
Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcom...