Over the past 15 years, MRI lesion activity has become the accepted surrogate primary outcome measure in proof-of-concept placebo-controlled clinical trials of new immunomodulating therapies in relapseonset multiple sclerosis (MS). In parallel, the number of patients that are available for the placebo arm of trials has declined, and more-aggressive drugs are being developed. A critical review is warranted to ensure efficient MRI—and patient—resource utilization. Recently, an international panel reviewed the methodology for efficient use of MRI-monitored trials in relapse-onset MS. In this article, we provide up-to-date recommendations for scan acquisition, image analysis, outcome-measure definition and standards of reporting. Factors ...
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing av...
Although the value of magnetic resonance imaging (MRI) for diagnosis/differential diagnosis of patie...
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing av...
Over the past 15 years, MRI lesion activity has become the accepted surrogate primary outcome measu...
Magnetic resonance imaging (MRI) provides a powerful tool for both monitoring disease evolution in m...
The need for more specific and more sensitive outcome measures for use in testing new therapies in m...
Objective: The aim of this work was to evaluate whether the treatment effects on magnetic resonance ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
INTRODUCTION: T2-weighted and gadolinium enhanced T1-weighted MRI scans measure plaque burden and br...
INTRODUCTION: T2-weighted and gadolinium enhanced T1-weighted MRI scans measure plaque burden and br...
Magnetic resonance imaging (MRI) is an important paraclinical tool for the diagnosis of multiple scl...
Background A meta-analysis of randomised trials in relapsing-remitting multiple sclerosis published ...
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing av...
Although the value of magnetic resonance imaging (MRI) for diagnosis/differential diagnosis of patie...
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing av...
Over the past 15 years, MRI lesion activity has become the accepted surrogate primary outcome measu...
Magnetic resonance imaging (MRI) provides a powerful tool for both monitoring disease evolution in m...
The need for more specific and more sensitive outcome measures for use in testing new therapies in m...
Objective: The aim of this work was to evaluate whether the treatment effects on magnetic resonance ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
BACKGROUND: Use of quantitative magnetic resonance imaging (MRI) metrics as surrogates for clinical ...
INTRODUCTION: T2-weighted and gadolinium enhanced T1-weighted MRI scans measure plaque burden and br...
INTRODUCTION: T2-weighted and gadolinium enhanced T1-weighted MRI scans measure plaque burden and br...
Magnetic resonance imaging (MRI) is an important paraclinical tool for the diagnosis of multiple scl...
Background A meta-analysis of randomised trials in relapsing-remitting multiple sclerosis published ...
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing av...
Although the value of magnetic resonance imaging (MRI) for diagnosis/differential diagnosis of patie...
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing av...