Infertility and psychiatric morbidity

OBJECTIVE: To assess the relationship between psychiatric disorders and infertility. DESIGN: Case-control study. SETTING: Fertile and infertile volunteer couples in an academic research setting. PATIENT(S): Eighty-one infertile couples recruited from an infertility center before fertility treatment and 70 fertile controls recruited from an obstetrics and gynecology clinic. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The presence of Axis 1 psychiatric disorders. RESULT(S): The occurrence of current psychiatric disorders was significantly higher among infertile subjects than among fertile controls, especially for adjustment disorder with mixed anxiety and depressed mood (16% vs. 2%) and for binge eating disorder (8% vs. 0). CONCLUSION(S): Our data highlight that a percentage of infertile patients have already developed a psychiatric disorder at the time of their first contact with a specialized fertility service. Possible applications are discussed, including the recommendation that gynecologists screen for clinical or subclinical psychiatric disorders in infertility patients and offer treatment accordingl