Unusual localizations of plasmacytoma
- Gozzetti A
- Coviello G
- Fabbri A
- Della Corte R
- Defina M
- Lauria F.
- BOCCHIA, MONICA
DOIAbstract
Multiple myeloma (MM) is a malignant proliferation of plasma cells in the bone marrow, usually producing a monoclonal paraprotein in the serum. Active disease can occur in different ways such as bone hypercalcemia, renal failure, anemia, and osteolytic lesions (CRAB definition of end organ damage) [1]. Uncommonly (<10% of cases), malignant plasma cells can be localized thus producing a single lytic lesion in the bone (solitary plasmacytoma of the bone, SPB) or a single mass involving soft tissues (extramedullary plasmacytoma, EP) in the absence of bone marrow infiltration and systemic disease. SPB usually involves the vertebral column, while EP usually affects the upper respiratory tract [2]. Both conditions tend to evolve to MM, but SPB do...
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