AIMS/HYPOTHESIS: Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. One of the proposed mechanisms of beta cell failure is local inflammation, but the presence of pancreatic islet inflammation in type 2 diabetes and the mechanisms involved remain under debate. METHODS: Chemokine and cytokine expression was studied by microarray analysis of laser-capture microdissected islets from pancreases obtained from ten non-diabetic and ten type 2 diabetic donors, and by real-time PCR of human islets exposed to oleate or palmitate at 6 or 28 mmol/l glucose. The cellular source of the chemokines was analysed by immunofluorescence of pancreatic sections from individuals without diabetes and with type 2 diabetes. RESULTS:...
Introduction Chronic inflammation is observed in type 2 diabetes islets, and fat deposition in the p...
Background: Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta...
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic is...
AIMS/HYPOTHESIS: Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. O...
AIMS/HYPOTHESIS: Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes....
Type 2 diabetes is a common complex disease. Relatively little is known about the underlying pathoph...
Onset of Type 2 diabetes occurs when the pancreatic beta-cell fails to adapt to the increased insuli...
SummaryConsumption of foods high in saturated fatty acids (FAs) as well as elevated levels of circul...
Aim: There is growing evidence that the beta-cell is central to the development of Type 2 diabetes. ...
Background: Diabetes is characterized by progressive failure of insulin producing beta cells. It is ...
Type 2 Diabetes (T2D) is strongly associated with obesity and characterized by chronic insulin resis...
Different degrees of beta-cell failure and apoptosis are present in type 1 and type 2 diabetes. It h...
Aims/hypothesis: Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been ...
Apoptosis is probably the main form of beta-cell death in both type 1 diabetes mellitus (T1DM) and T...
Background: Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta...
Introduction Chronic inflammation is observed in type 2 diabetes islets, and fat deposition in the p...
Background: Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta...
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic is...
AIMS/HYPOTHESIS: Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. O...
AIMS/HYPOTHESIS: Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes....
Type 2 diabetes is a common complex disease. Relatively little is known about the underlying pathoph...
Onset of Type 2 diabetes occurs when the pancreatic beta-cell fails to adapt to the increased insuli...
SummaryConsumption of foods high in saturated fatty acids (FAs) as well as elevated levels of circul...
Aim: There is growing evidence that the beta-cell is central to the development of Type 2 diabetes. ...
Background: Diabetes is characterized by progressive failure of insulin producing beta cells. It is ...
Type 2 Diabetes (T2D) is strongly associated with obesity and characterized by chronic insulin resis...
Different degrees of beta-cell failure and apoptosis are present in type 1 and type 2 diabetes. It h...
Aims/hypothesis: Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been ...
Apoptosis is probably the main form of beta-cell death in both type 1 diabetes mellitus (T1DM) and T...
Background: Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta...
Introduction Chronic inflammation is observed in type 2 diabetes islets, and fat deposition in the p...
Background: Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta...
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic is...