Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia
- FERRARI, MARCO
- Bolla, Emilio
- BORTOLASO, PAOLA
- CALLEGARI, CAMILLA
- POLONI, NICOLA
- LECCHINI, SERGIO
- VENDER, SIMONE
- MARINO, FRANCA
- COSENTINO, MARCO
Publication date
January 2012
DOI ISSN
0165-1781 Citation count (estimate)
17Abstract
We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019). © 2012 Elsevier Ireland Ltd
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