Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis
- Kouvidi, Katerina
- Berdiaki, Aikaterini
- Tzardi, Maria
- KAROUSOU, EVGENIA
- PASSI, ALBERTO
- Nikitovic, Dragana
- Tzanakakis, George N.
Publication date
January 2016
DOI ISSN
0304-4165 Citation count (estimate)
7Abstract
High levels of hyaluronan (HA) synthesis in various cancer tissues, including sarcomas, are correlated with tumorigenesis and malignant transformation. RHAMM (receptor for hyaluronic acid-mediated motility) is overexpressed during tumor development in different malignancies. β-Catenin is a crucial downstream mediator of the Wnt signaling cascade which facilitates carcinogenic events characterized by deregulated cell proliferation
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