Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions
- Doro, Fabio
- Colombo, Cinzia
- Alberti, Chiara
- Arosio, Daniela
- Belvisi, Laura
- Casagrande, Cesare
- Fanelli, Roberto
- Manzoni, Leonardo
- Parisini, Emilio
- Piarulli, Umberto
- Luison, Elena
- Figini, Mariangela
- Tomassetti, Antonella
- Civera, Monica
Publication date
January 2015
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
1477-0520Abstract
We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients
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