Does enhancement of oxidative stress markers mediate health effects of ambient air particles?
- P. A. Bertazzi
- L. Cantone
- P. Pignatelli
- L. Angelici
- V. Bollati
- M. Carugno
- P. M. Mannucci
- F. Violi
- BONZINI, MATTEO
DOIAbstract
Abstract Evidence indicates that oxidative stress generation may contribute to health effects associated with particulate matter (PM) exposure. We investigated oxidative stress markers in 113 workers exposed to metal-rich PM and 61 nonexposed comparable volunteers. The plasma levels of soluble NOX2-derived peptide (sNOX2-dp) and two oxidative stress markers, urinary 8-hydroxydeoxyguanosine (8-OHdG) and 8-iso-prostaglandinF2alpha (8-iso-PGF2α), were analyzed. The plasma levels of the antioxidant alpha-tocopherol were also evaluated. The workers' average exposure to PM with an aerodynamic diameter <10 μm (PM10) was much higher at the workplace than in the city, where the volunteers lived. Workers had significantly higher urinary 8-iso-PGF2α a...
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