Experiments with Xenopus oocytes and embryos have determined a direct biochemical relationship between chromatin structure and transcription. Nucleosomes within specific nucleoprotein architectures can either activate or repress transcription. Developmentally regulated changes in chromosomal composition direct the dominant repression of specific genes. Reconstruction of chromatin templates in vivo establishes that replication-coupled chromatin assembly both represses basal transcription and facilitates a full range of inducible gene activity. Chromatin structure emerges as a major contributory factor to the regulation of genes
Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, i...
AbstractThe earliest steps of embryonic development involve important changes in chromatin and trans...
The accessibility of DNA in chromatin to psoralen was assayed to compare the chromatin structure of ...
Experiments with Xenopus oocytes and embryos have determined a direct biochemical relationship betwe...
The relationship of chromatin structure to func-tional genomic activity is unclear at the present ti...
Contains fulltext : 236639.pdf (Publisher’s version ) (Open Access)Radboud Univers...
Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of protei...
Contains fulltext : 169128.pdf (publisher's version ) (Open Access)Radboud Univers...
Much of biological complexity is achieved through regulated gene expression. In eukaryotes the rst s...
Recent work suggests that the chromatin structure of genes is precisely organized, as indicated by t...
Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not ...
led scientists to realize the pivotal roles of nonhistone pro- tacts with GTFs before it proceeds on...
The intranuclear DNA of all eukaryotic cells is packed into chromatin, generating a repressive envir...
Packaging of the eukaryotic genome into chromatin places fundamental physical constraints on transcr...
The fertilized frog egg contains all the materials needed to initiate development of a new organism,...
Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, i...
AbstractThe earliest steps of embryonic development involve important changes in chromatin and trans...
The accessibility of DNA in chromatin to psoralen was assayed to compare the chromatin structure of ...
Experiments with Xenopus oocytes and embryos have determined a direct biochemical relationship betwe...
The relationship of chromatin structure to func-tional genomic activity is unclear at the present ti...
Contains fulltext : 236639.pdf (Publisher’s version ) (Open Access)Radboud Univers...
Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of protei...
Contains fulltext : 169128.pdf (publisher's version ) (Open Access)Radboud Univers...
Much of biological complexity is achieved through regulated gene expression. In eukaryotes the rst s...
Recent work suggests that the chromatin structure of genes is precisely organized, as indicated by t...
Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not ...
led scientists to realize the pivotal roles of nonhistone pro- tacts with GTFs before it proceeds on...
The intranuclear DNA of all eukaryotic cells is packed into chromatin, generating a repressive envir...
Packaging of the eukaryotic genome into chromatin places fundamental physical constraints on transcr...
The fertilized frog egg contains all the materials needed to initiate development of a new organism,...
Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, i...
AbstractThe earliest steps of embryonic development involve important changes in chromatin and trans...
The accessibility of DNA in chromatin to psoralen was assayed to compare the chromatin structure of ...