MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity

MORERIO C
RAPELLA A
ROSANDA C
LANINO E
LO NIGRO L
DI CATALDO A
MASERATI E
PASQUALI F.
PANARELLO C

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Publication date

January 2004

DOI

10.1016/j.cancergencyto.2003.11.012

ISSN

0165-4608

Citation count (estimate)

Abstract

Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneit