Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication
- T. M. ALLEN
- B. MOTH
- M. LIEBL
- P. JING
- B. CALORE
- M. PIEKARCZYK
- R. RUDDERSDORF
- D. H. OCONNOR
- X. WANG
- C. X. WANG
- D. B. ALLISON
- J. D. ALTMAN
- A. SETTE
- R. DESROSIERS
- G. SUTTER
- D. I. WATKINS
- MORTARA, LORENZO
DOIAbstract
The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls
Add to ORKG