Association of Early MRI Characteristics with Subsequent Epilepsy and Neurodevelopmental Outcomes in Children with Tuberous Sclerosis Complex

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Publication date

March 2022

DOI

10.1212/wnl.0000000000200027

Publisher

Ovid Technologies (Wolters Kluwer Health)

Abstract

Background and ObjectivesMultiple factors have been found to contribute to the high risk of epilepsy in infants with tuberous sclerosis complex (TSC), including evolution of EEG abnormalities, TSC gene variant, and MRI characteristics. The aim of this prospective multicenter study was to identify early MRI biomarkers of epilepsy in infants with TSC aged <6 months and before seizure onset, and associate these MRI biomarkers with neurodevelopmental outcomes at 2 years of age. The study was part of the EPISTOP project.MethodsWe evaluated brain MRIs performed in infants younger than 6 months with TSC. We used harmonized MRI protocols across centers and children were monitored closely with neuropsychological evaluation and serial video EEG. MRI ...