Fibrinogen gamma ' levels in patients with intracerebral hemorrhage

Background: The fibrinogen gamma' variant (gamma') has both antithrombotic and prothrombotic properties when compared to normal fibrinogen. It may therefore be of relevance in intracerebral hemorrhage and intraventricular extension of the bleeding. Objective: To study the role of gamma' in intracerebral hemorrhage, and in intraventricular extension of the hemorrhage. Patients/Methods: We performed a case-control study in 156 controls and 55 patients with intracerebral hemorrhage, with and without intraventricular extension. Levels of fibrinogen gamma' and the gamma'/total fibrinogen ratio were measured in all participants. Results: Levels of gamma' were increased in patients with intracerebral hemorrhage when compared with controls (0.40 vs 0.32 g/l, p