Salvage rates and prognostic factors after relapse in children and adolescents with initially localised synovial sarcoma

Andrea, Ferrari
Gian Luca De, Salvo
Cristina, Meazza
Francesco De, Leonardis
Carla, Manzitti
Maria Antonietta de, Ioris
Michela, Casanova
Modesto, Carli
Bisogno, Gianni

Open link

Publication date

January 2012

DOI

10.1016/j.ejca.2012.06.017

Publisher

Elsevier BV

ISSN

0959-8049

Citation count (estimate)

Abstract

Background: Previous studies have reported a poor outcome for synovial sarcoma patients whose tumours relapse. Methods: This study analysed 44 relapsing cases in a series of 118 consecutive patients <21 yr of age with non-metastatic synovial sarcoma prospectively enrolled in Italian paediatric protocols between 1979 and 2006. In an effort to identify a possible risk-adapted stratification enabling a better planning of second-line treatment, the relapsing patients' outcome was analysed vis-a-vis their clinical picture at onset, first-line treatments, clinical findings at the time of first relapse and second-line treatment modalities. Results: The first event was a local recurrence in only 15 cases, and metastatic in 29 (associated with loc...