Persistent pain affects nearly half of all people seeking medical care in the US alone, and accounts for at least $80 billion worth of lost productivity each year. Among all types of chronic pain, neuropathic pain stands out: this is pain resulting from damage or disease of the somatosensory nervous system, and remains largely untreatable. With few available treatment options, neuropathic pain represents an area of significant and growing unmet medical need. Current treatment of peripheral neuropathic pain involves several drug classes, including opioids, gabapentinoids, antidepressants, antiepileptic drugs, local anesthetics and capsaicin. Even so, less than half of patients achieve partial relief. This review discusses a novel approach to...
Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, an...
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to am...
Some 30-50% of the global population and almost 20% of the European population actually suffer from ...
Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are ex...
Inflammation is fundamentally a protective cellular response aimed at removing injurious stimuli and...
Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous prot...
he existence of acylethanolamides (AEs) in the mammalian brain has been known for decades. Among AEs...
Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed ...
Background: Neuropathic pain is defined by International Association for the Study of Pain (IASP) as...
Copyright © 2014 Chiara Schifilliti et al.This is an open access article distributed under theCreati...
Neuropathic pain and spasticity after spinal cord injury (SCI) represent significant problems. Palmi...
Jan M Keppel Hesselink, David J Kopsky Institute for Neuropathic Pain, Bosch en Duin, the Nethe...
Neuropathic pain can have a major effect on quality of life but current therapies are often inadequa...
Background: Enhanced supraspinal glutamate levels following nerve injury are associated with pathoph...
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to am...
Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, an...
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to am...
Some 30-50% of the global population and almost 20% of the European population actually suffer from ...
Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are ex...
Inflammation is fundamentally a protective cellular response aimed at removing injurious stimuli and...
Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous prot...
he existence of acylethanolamides (AEs) in the mammalian brain has been known for decades. Among AEs...
Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed ...
Background: Neuropathic pain is defined by International Association for the Study of Pain (IASP) as...
Copyright © 2014 Chiara Schifilliti et al.This is an open access article distributed under theCreati...
Neuropathic pain and spasticity after spinal cord injury (SCI) represent significant problems. Palmi...
Jan M Keppel Hesselink, David J Kopsky Institute for Neuropathic Pain, Bosch en Duin, the Nethe...
Neuropathic pain can have a major effect on quality of life but current therapies are often inadequa...
Background: Enhanced supraspinal glutamate levels following nerve injury are associated with pathoph...
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to am...
Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, an...
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to am...
Some 30-50% of the global population and almost 20% of the European population actually suffer from ...