This essay will present a documented Italian history of secrets devised in the late seventeenth century in an ordinary household, then temporarily brought into the world of (supposed) charlatanry and eventually taken on, from the end of the eighteenth up to the early twentieth century, by apothecaries. Drawing on a range of primary sources and a few printed texts analysed for their content and material features, the study provides a multi-generational portrait of handlers of medicinal secrets involving both male and female members, whom we might more accurately define as artisans of medicinal secrets rather than quacks, empirics or anything else. It is certain that Venetian medical legislation defined them as 'particular people'. The case s...