Additional file 8 of Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

Additional file 8: Figure S1. Cellular landscape of CRC in the KUL3 cohort. A. UMAP plot of 26,268 cells colored by cell cluster, CMS and sample origin. Each dot represents a cell and cellular cluster is annotated with text. B. Proportions of the identified cell clusters distributed across tumor, border and adjacent normal tissues with the relative cell type proportions and total cell numbers. Upper: all cell clusters; lower: immune and stromal cell clusters. C. Heatmap of representative markers for the cell clusters. A total of 100 random cells in each cluster were chosen for visualization. The color legend is as in B. D. Frequencies of the selected cell types for tumor, border and adjacent normal samples. The Kruskal-Wallis test p value is shown