Synthesis and biological activity of imidazolium salts

Poznata je široka primjena kvaternih amonijevih soli imidazola pa tako i njihova antibakterijska i antifungalna svojstva. Provedene su jednostavne reakcije kvaternizacije imidazola, 1-vinilimidazola i 4-metilimidazola s alkil-halogenidom pri čemu je alkilni lanac (R) varirao između 12 i 20 ugljikovih atoma, a za halogenid (X) je uzet bromid ili jodid. Reakcije su se odvijale u bazičnim uvjetima uz acetonitril kao otapalo, u zatvorenoj inertnoj atmosferi dušika pri 100°C ili na sobnoj temperaturi. Uspješno je sintetizirano deset kvaternih amonijevih soli imidazola. Dobiveni spojevi su izolirani i karakterizirani infracrvenom spektroskopijom (IR) te masenom spektrometrijom (MS). Potencijalna antibakterijska svojstva sintetiziranih spojeva nisu ispitivana u ovome radu.Widespread use of quaternary ammonium salts of imidazole is known, as well as their antibacterial and antifungal properties. Simple quaternization reactions of imidazole, 1-vinylimidazole and 4-methylimidazole with alkyl halide were carried out with the alkyl chain (R) varying between 12 and 20 carbon atoms and the bromide or iodide taken as the halide (X). The reactions were performed under basic conditions with acetonitrile as solvent, under a closed inert nitrogen atmosphere at 100° C or at room temperature. Ten quaternary ammonium salts of imidazole have been successfully synthesized. The obtained compounds were isolated and characterized by infrared spectroscopy and mass spectrometry. The potential antibacterial properties of the synthesized compounds have not been investigated in this paper