CLINICAL FEATURES OF PATIENTS WITH INVASIVE BLADDER CANCER

Karcinom mokraćnog mjehura je jedan od najčešćih karcinoma te zauzima značajno mjesto u stopama mortaliteta i incidencije na razini RH i svijeta. Svrha ovog rada jest prikazati i usporediti kliničke značajke bolesnika koji su operirani zbog mišićno invazivnog karcinoma mokraćnog mjehura kroz tri godine. U ovo su ispitivanje uvršteni bolesnici koji su u razdoblju od 1. siječnja 2017.godine do 31. prosinca 2019. godine podvrgnuti operativnom zahvatu na Klinici za urologiju Kliničkog bolničkog centra Rijeka zbog invazivnog karcinoma mokraćnog mjehura. Bolesnici su podijeljeni obzirom na metodu urinarne derivacije koja je kod njih provedena. Analizirane su demografske i kliničke značajke bolesnika. Ukupno je 97 bolesnika podvrgnuto operativnom zahvatu. Od toga 75 (77,3%) su bili muškarci, a 22 (22,6%) žene. Prosječna je dob bolesnika bila 70 godina i 4 mjeseca. Ureterokutaneostoma je učinjena kod 47 bolesnika, ileum conduit po Brickeru je učinjen kod 20 bolesnika, neovezika po Studeru kod 14, a neovezika po Hautmannu kod 13 bolesnika. Jedna je bolesnica bila anefrična i kod nje nije učinjena urinarna derivacija, a jednom je bolesniku postavljena nefrostomija. Prosječna je vrijednost eGFRa iznosila 63,2mL/1,73m2/s, a prosječna razina serumskog kreatinina 134,9µmol/L. Bolesnici s neovezikom po Studeru su imali prosječno najviše vrijednosti eGFRa, a najniže su zabilježene kod bolesnika s ureterokutaneostomom. MIBC se češće javlja kod muškaraca i starijih osoba. Najčešći je početni simptom hematurija. Najčešća je primijenjena metoda liječenja radikalna cistektomija uz moguću primjenu radioterapije te neoadjuvantne i adjuvantne kemoterapije.Bladder cancer is one of the mmost common types of cancer. Bladder cancer occupies a significant spot in the mortality and incidence rates in Croatia and in the rest of the world. The purpose of this paper is to present and compare the clinical features of the patients that underwent surgery through three years. This study included patients which underwent surgery for invasive bladder cancer between January 1st, 2017, and December 31st, 2019, at the Department of Urology of the Clinical Hospital Center Rijeka. Patients were divided according to the urinary derivation method used on each patient and their data were evaluated. Demographics and clinical characteristics of the patients were analyzed. A total of 97 patients underwent surgery. Out of these, 22 (22.6%) were female and 75 (77.3%) were male. The average age of the patients was 70 years and 4 months. 47 patients had ureterocutaneostomies done, along with 20 ileum conduits according to Bricker, 14 Studer neobladders, and 13 Hautmann neobladders. One patient was anephric and no urinary diversion was performed and one patient got a nephrostomy. Mean serum creatinine levels were 134.9 µmol/L and 63.2 mL/1.73 m2 /s, respectively, for eGFR. The patients with Studer neobladder had the highest average eGFR rate, while patients with ureterocutaneostomy had the lowest values. Men and older people are more likely to have MIBC. Hematuria is the most typical first sign. Radiation therapy, preoperative chemotherapy, and adjuvant chemotherapy may be utilized in addition to the most popular treatment option, radical cystectomy