BACKGROUND: Some osteoarthritis (OA) patients experience inadequate pain relief from analgesics like acetaminophen and nonsteroidal anti-inflammatory drugs. This could be the result of experienced non-nociceptive centralized pain. Placebo-controlled randomized trials (RCT) have proven the effectiveness of duloxetine for OA and several chronic pain conditions where central sensitization (CS) is one of the key underlying pain mechanisms. OBJECTIVES: Assess the efficacy of an 8-week duloxetine treatment compared to usual care in end-stage knee and hip OA patients with a level of centralized pain. DESIGN: Pragmatic, enriched, open-label RCT. METHODS: Patients were randomized to duloxetine or to care-as-usual. Primary outcome was pain in the ind...
Yuji Uchio,1 Hiroyuki Enomoto,2 Mitsuhiro Ishida,3 Toshinaga Tsuji,4 Toshimitsu Ochiai,5 Shinichi Ko...
Abstract Background The objectives of this study were to assess the maintenance of effect of duloxet...
Introduction: Knee osteoarthritis (OA) is a common form of arthritis in elders which can lead to red...
BACKGROUND: Some osteoarthritis (OA) patients experience inadequate pain relief from analgesics like...
__Introduction__ Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal ...
__Introduction__ Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal ...
Introduction Residual pain is a major factor in patient dissatisfaction following total hip arthropl...
Background: Pain is the leading symptom of knee osteoarthritis (OA) leading to significant morbidity...
About 21% of adults with osteoarthritis (OA) are diagnosed with concomitant depression in addition t...
Li Yue,1 Sheng Luo,2 Yiwen Wang,1 Chia-Ning Wang,1 Héctor José Dueñas,3 Vladimi...
Yuji Uchio,1 Hiroyuki Enomoto,2 Levent Alev,2 Yuki Kato,3 Hiroyuki Ishihara,3 Toshinaga Tsuji,4 Tosh...
Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in ...
OBJECTIVES: A key predictor for developing chronic residual pain after total knee or hip arthroplast...
Introduction Residual pain is a major factor in patient dissatisfaction following total hip arthropl...
Naohiro Itoh,1 Toshinaga Tsuji,1 Mitsuhiro Ishida,2 Toshimitsu Ochiai,3 Shinichi Konno,4 Yuji Uchio5...
Yuji Uchio,1 Hiroyuki Enomoto,2 Mitsuhiro Ishida,3 Toshinaga Tsuji,4 Toshimitsu Ochiai,5 Shinichi Ko...
Abstract Background The objectives of this study were to assess the maintenance of effect of duloxet...
Introduction: Knee osteoarthritis (OA) is a common form of arthritis in elders which can lead to red...
BACKGROUND: Some osteoarthritis (OA) patients experience inadequate pain relief from analgesics like...
__Introduction__ Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal ...
__Introduction__ Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal ...
Introduction Residual pain is a major factor in patient dissatisfaction following total hip arthropl...
Background: Pain is the leading symptom of knee osteoarthritis (OA) leading to significant morbidity...
About 21% of adults with osteoarthritis (OA) are diagnosed with concomitant depression in addition t...
Li Yue,1 Sheng Luo,2 Yiwen Wang,1 Chia-Ning Wang,1 Héctor José Dueñas,3 Vladimi...
Yuji Uchio,1 Hiroyuki Enomoto,2 Levent Alev,2 Yuki Kato,3 Hiroyuki Ishihara,3 Toshinaga Tsuji,4 Tosh...
Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in ...
OBJECTIVES: A key predictor for developing chronic residual pain after total knee or hip arthroplast...
Introduction Residual pain is a major factor in patient dissatisfaction following total hip arthropl...
Naohiro Itoh,1 Toshinaga Tsuji,1 Mitsuhiro Ishida,2 Toshimitsu Ochiai,3 Shinichi Konno,4 Yuji Uchio5...
Yuji Uchio,1 Hiroyuki Enomoto,2 Mitsuhiro Ishida,3 Toshinaga Tsuji,4 Toshimitsu Ochiai,5 Shinichi Ko...
Abstract Background The objectives of this study were to assess the maintenance of effect of duloxet...
Introduction: Knee osteoarthritis (OA) is a common form of arthritis in elders which can lead to red...