Secondary metabolites from marine derived Aspergillus species and their activities

Gljivice roda Aspergillus proizvode jedinstvene metabolite od kojih veliki broj ima obećavajuću farmakološku aktivnost. Ovaj diplomski rad daje pregled sekundarnih metabolita koji su pokazali značajno antibakterijsko, antivirusno, antifungalno i antitumorsko djelovanje. Sve skupa ovaj rad pokriva 99 metabolita koji su otkriveni u razdoblju od 2005. do 2019. godine. Među biološki aktivnim metabolitima s antimirkobnim djelovanjem ističu se preusin (djeluje na gram-pozitivne bakterije, MRSA i VRE), 14-norpseurotin, 6β,16β-diacetoksi-25-hidroksi-3,7dioksi-29-nordamara- 1,17(20)-dien-21-oička kiselina (djeluju na gram-negativne i gram-pozitivne bakterije), 24- hidroksilergosta-4,6,8(14),22-tetraen-3-on, kotanin, 4,4-dimetoksi-5,5-dimetil-7,7-oksidikumarin, ohraceopon A i izoasteltoksin, a klavatustid A i B, ustusoran E, i aspergiolid A istaknuli su se svojim antitumorskim djelovanjem. Iz tih podataka može se zaključiti da su sekundarni metaboliti gljivica iz roda Aspergillus dobri modeli za razvoj novih antimikrobnih i antitumorskih lijekova.Species of the Aspergillus genus are capable of producing unique metabolites, a considerable number of which display promising pharmacological activity. This diploma thesis gives an overview of secondary metabolites which showed some considerable antibacterial, antiviral, antifungal or citotoxic activity. Overall, 99 metabolites which were discovered in the period from 2005 until 2019 are presented. Among all biologically active products the most important ones with antimicrobial activities are preussin (shows antibacterial activity towards gram-positive bacteria, MRSA, VRE), 14-norpseurotine, 6β,16β-diacetoxy-25-hidroxy-3,7dioxy-29-nordammara-1,17(20)-dien-21-oic acid, (shows antibacterial activity towards gram-negative and gram-positive bacteria), kotanin, 24- hidroxylergosta-4,6,8(14),22-tetraen-3-one, 4,4-dimethoxy-5,5-dimethyl-7,7-oxydicoumarin, ochraceopone A and isoasteltoxin, while clavatustides A, B, ustusorane E, and aspergiolide A showed significant anticancer activity. From this data, it can be deduced that secondary metabolites from Aspergillus species could be used as good models for developement of new antimicrobial and anticancer drugs