Produljeno aktivirano parcijalno tromboplastinsko vrijeme - prikaz slučaja

A case of a 75-year-old female referred to our hospital for hip replacement with preoperative laboratory test of prolonged activated partial thromboplastin time due to factor XII deficiency is described. Other coagulation parameters known to be associated with prolonged activated partial thromboplastin time like factor VIII, factor IX, factor XI, high-molecular-weight kininogen and prekallikrein were normal, and there was no evidence for the presence of unspecified circulating anticoagulants or heparin. There is a general consensus that factor XII deficiency usually does not result in hemorrhagic diathesis. Its relationship with overt venous thrombosis is still unclear. The patient and her family had no history of bleeding disorder or thromboembolic events. There was no excessive bleeding or thromboembolic incident during the surgery and postoperative recovery.Prikazan je slučaj 75-godišnje bolesnice upućene u našu bolnicu radi ugradnje umjetnog kuka s prijeoperacijskim nalazom produljenog aktiviranog parcijalnog tromboplastinskog vremena zbog nedostatka faktora XII. Drugi čimbenici koji mogu uzrokovati produljenje aktiviranog parcijalnog tromboplastinskog vremena kao faktor VIII, faktor IX, faktor XI, kininogen visoke molekularne mase i prekalikrein su bili uredni, a nije bilo znakova prisutnosti cirkulirajućih antikoagulansa niti heparina. Opći stav je da nedostatak faktora XII uglavnom ne uzrokuje krvarenje, dok je još nejasna povezanost s tromboembolijom. U bolesnice i njene obitelji nije bilo anamnestičkih podataka o poremećaju krvarenja niti tromboembolije. Za vrijeme kirurškog zahvata i u poslijeoperacijskom razdoblju nije bilo značajnog krvarenja niti tromboembolije