Lactulose breath test to assess oro-cecal transit delay and estimate esophageal dysmotility in scleroderma patients.

Gemignani, L
Savarino, V
Ghio, M
Parodi, A
Zentilin, P
de Bortoli, N
Negrini, S
Furnari, M
Dulbecco, P
Giambruno, E
Savarino, EDOARDO VINCENZO

Open link

Publication date

January 2013

DOI

10.1016/j.semarthrit.2012.09.004

Publisher

Elsevier BV

ISSN

0049-0172

Citation count (estimate)

Abstract

Abstract OBJECTIVES: To assess the correlation between delayed oro-cecal transit time (OCTT) and esophageal motility abnormalities in a cohort of systemic sclerosis (SSc) patients. METHODS: We prospectively enrolled 50 consecutive SSc patients and 60 healthy volunteers (HVs) as controls. Both groups underwent glucose breath test (GBT) to exclude small intestine bacterial overgrowth, lactulose hydrogen, and octanoic acid breath tests (LHBT and OBT) to measure OCTT and gastric emptying (GE), respectively, and manometry to assess esophageal motility. RESULTS: Thirty-one (63%) SSc patients presented ineffective esophageal motility (IEM) compared with 3 HVs (5%; P180min, P<0.01). CONCLUSIONS: Abnormalities of both esophageal and small intestine ...