Nutrition May Modulate Microbioma Of Preterm Neonates

Human milk is generally accepted as the best nutrition for newborns and has been shown to support the optimal microbioma, growth and development of infants. Milk from women who deliver prematurely differs from that of women who deliver at term. For example premature milk is richer in glucosaminoglycans (GAG) ,which appear to act as decoys providing binding sites for pathogenic bacteria to prevent adherence to the enterocyte, than term milk. A dose of mother’s own milk > 50 ml/kg/d decreases the risk of newborn hospital readmission rate. In this study we examined breast milk samples of 30 mothers of preterm infant, in their raw and different storage and supplementation stages. Tested samples were colostrums, transitional milk, mature milk (PBM), in raw stage, and in different stage of pasteurization and storage pasteurized mature milk, milk after 48h storage at 4C, milk after 7d storage at -20C, milk after 7d storage at -20C and pasteurized, milk after 30d storage at -20C, milk after 30d storage at - 20C, and pasteurized; PBM supplemented with fortifier (PBM+FF) and infant formula for premature infants (IF PRE). It is well known that antioxidants may influence microbiome. According to measured total antioxidant capacity the best solution for premature babies nutrition is preterm mature milk with fortifier