The present study aimed to assess the effect of NO• on melanoma A375 cell growth and apoptotic cell death. Trypan blue exclusion assay was employed to detect the cytotoxicity induced by controlled steady-state concentrations (given in µM • min) of NO•. The characteristics of the cellular cell cycle and apoptosis in NO•-treated A375 cells were also analyzed by Annexin V/PI and DNA fragmentation assays. Western blotting was applied to detect the expression of apoptosis-related proteins (p53, Bax, Fas, DR5, caspase-3 and -9, and PARP). When exposed to preformed 100% NO• for 8 h reactor system, a cumulative dose of 3360 μM • min reduced the viability by 22% 24 h after treatment and promoted apoptosis, 2.9- and 12.2-folds 24 and 48 h after treat...
Human cutaneous melanoma is the most aggressive form of skin cancer and the incidence rates have con...
AbstractNitric oxide (NO) is a diffusible messenger involved in several patho-physiological processe...
Nitric oxide (NO) is known to exert cytotoxic and cytostatic effects in various cells and tissues. A...
Purpose: To examine the role of endogenous nitric oxide (NO•) and influence of p53 status during apo...
In this study we evaluated the effects of the new NO donating compound (S,R)-3-phenyl-4,5-dihydro-5-...
Nitric oxide is involved in a multitude of processes including regulation of vascular tone, neurotra...
Our previous studies have shown that nitric oxide (NO) plays an important role in increasing the inv...
We have recently shown in B16F10 melanoma cells that blockade of β3-adrenergic receptors (β3-ARs) re...
Aims: Our previous studies have shown that nitric oxide (NO) plays an important role in increasing t...
Susceptibility of dendritic cells (DCs) to tumor-induced apoptosis reduces their efficacy in cancer ...
We have recently shown in B16F10 melanoma cells that blockade of β3-adrenergic receptors (β3-ARs) re...
Interferon-gamma (IFN-γ) is shown to stimulate melanoma development and progression. However, the un...
NO• is a free radical and is involved in a number of critical physiological processes including vaso...
It is well recognized that nitric oxide (NO) is involved in tumor progression, including melanoma. M...
Melanoma patients experience inferior survival after biochemotherapy when their tumors contain numer...
Human cutaneous melanoma is the most aggressive form of skin cancer and the incidence rates have con...
AbstractNitric oxide (NO) is a diffusible messenger involved in several patho-physiological processe...
Nitric oxide (NO) is known to exert cytotoxic and cytostatic effects in various cells and tissues. A...
Purpose: To examine the role of endogenous nitric oxide (NO•) and influence of p53 status during apo...
In this study we evaluated the effects of the new NO donating compound (S,R)-3-phenyl-4,5-dihydro-5-...
Nitric oxide is involved in a multitude of processes including regulation of vascular tone, neurotra...
Our previous studies have shown that nitric oxide (NO) plays an important role in increasing the inv...
We have recently shown in B16F10 melanoma cells that blockade of β3-adrenergic receptors (β3-ARs) re...
Aims: Our previous studies have shown that nitric oxide (NO) plays an important role in increasing t...
Susceptibility of dendritic cells (DCs) to tumor-induced apoptosis reduces their efficacy in cancer ...
We have recently shown in B16F10 melanoma cells that blockade of β3-adrenergic receptors (β3-ARs) re...
Interferon-gamma (IFN-γ) is shown to stimulate melanoma development and progression. However, the un...
NO• is a free radical and is involved in a number of critical physiological processes including vaso...
It is well recognized that nitric oxide (NO) is involved in tumor progression, including melanoma. M...
Melanoma patients experience inferior survival after biochemotherapy when their tumors contain numer...
Human cutaneous melanoma is the most aggressive form of skin cancer and the incidence rates have con...
AbstractNitric oxide (NO) is a diffusible messenger involved in several patho-physiological processe...
Nitric oxide (NO) is known to exert cytotoxic and cytostatic effects in various cells and tissues. A...